Avocado and Soybean Unsaponifiables For Osteoarthritis

The Cochrane Review on the use of Avocado/soybean unsaponificables in osteoarthritis lacked attention to these food additives. That is why one reader complained that the Cochrane review did not mention food additives for osteoarthritis. In fact, a quick search of the Cochrane review revealed a third study that suggested efficacy of this additive.

Side effects

Researchers have studied the effects of avocado-soybean-unsaponifiables on the deterioration of the cartilage and bone in a dog model of osteoarthritis. The study concluded that ASUs slow the radiographic progression of osteoarthritic cartilage. However, there are several side effects associated with their use.

In one study, ASUs reduced the number of chondrocytes in patients with OA. Chondrocytes stained positive for iNOS were predominantly located in the superficial zone of the cartilage. However, in the ASU-treated group, the percentage of positive cells decreased. Morphometric analysis of chondrocytes stained with iNOS was performed using a Mann-Whitney two-tailed U-test. A P=0.05 was considered statistically significant.

Mechanism of action

ASU, or avocado-soybean triglycerides, has shown promise as a treatment for temporomandibular joint arthritis, arthralgia, and autoimmune diseases. ASU inhibits the production of PGE2, nitric oxide, and MMPs in joint tissue, exerting anabolic and anti-catabolic effects on cartilage metabolism. Its anabolic properties have also led to its application as a menopausal health supplement.

Acai berries, avocado/soybean unsaponifs, and lipoic acid may also inhibit the production of inflammatory mediators in connective tissues and reduce the symptoms of osteoarthritis. In addition, they can inhibit the production of inflammatory mediators, such as cytokines, leukotrienes, and nitric oxide.


The efficacy of avocado-soybeans-unsaponifiables in the treatment of osteoarthritis has been examined in several clinical trials. These have demonstrated that these food additives can decrease radiographic progression and increase synthesis of aggrecans. Avocado-soybean unsaponifiables inhibit the production of MMP-13 and inducible nitric oxide synthase, which are two important mediators involved in structural changes associated with osteoarthritis.

ASU is an extract from the seeds of the avocado and soybean plant. This compound is thought to interfere with various cellular mediators, including interleukins, which cause the breakdown of synovial tissue. It is also thought to promote collagen synthesis in culture. The effectiveness of avocado-soybean oils in treating osteoarthritis has been assessed in several clinical trials, including one conducted by Dr. Henri Thiers in the 1950s. The study used a prospective double-blind placebo-controlled multicenter clinical trial.


Researchers have examined the effects of avocado-soybean unsaponiables on bone loss and repair in a dog model of osteoarthritis. In particular, these unsaponifiables reduce calcified cartilage thickness and subchondral bone volume. The research team believes that avocado-soybean-unsaponifiables may help treat osteoarthritis of the temporomandibular joint.

A recent study published in Reumatology suggests that patients with knee or hip osteoarthritis may benefit from dietary supplements containing avocado-soybean unsaponifiers. Patients in the study were given a 300 mg capsule of ASU per day, without the use of other medications. Overall, 86.8% of patients completed the study, with results indicating a significant reduction in pain and disability. Additionally, patients who took ASUs were less likely to use NSAIDs during the study, thereby reducing their risk of side effects.

Alternative to NSAIDs

A new study shows that a plant supplement called avocado-soybean unsapnifiables (ASUs) may slow the radiographic progression of hip osteoarthritis. The results of this study are promising, and scientists are hoping to learn more about its uses in future research. However, many physicians are leery of the use of plant supplements as a substitute for NSAIDs for osteoarthritis.

Although ASUs are not considered a natural drug, they have many positive benefits and can help ease pain in arthritic joints. ASU-based products are made from a blend of soybean and avocado unsaponifiables, with a 1:2 ratio, which makes them effective in treating osteoarthritis. Many patients who suffer from osteoarthritis are turning to natural therapies as an alternative to prescription drugs, as they are believed to be safer and have fewer unwanted side effects.

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